Antibiotic Tolerance and Combination Therapy
نویسندگان
چکیده
منابع مشابه
Antibiotic Tolerance and Combination Therapy
The recent paper by Haaber et al. (1) highlights another mechanism by which bacterial pathogens may evade the effects of antibiotics. The combination of colistin with vancomycin against Staphylococcus aureus may be antagonistic and may lessen the effectiveness of glycopeptide antibiotic. Colistin, it seems, induces gene expression in S. aureus which mimics the vancomycinintermediate (VISA) phen...
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Community-acquired pneumonia (CAP) is a common and potentially serious illness that is associated with morbidity and mortality. Although medical care has improved during the past decades, it is still potentially lethal. Streptococcus pneumoniae is the most frequent microorganism isolated. Treatment includes mandatory antibiotic therapy and organ support as needed. There are several antibiotic t...
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Despite the availability of new and potent antibiotics, modern echocardiography, and advanced surgical techniques, infective endocarditis (IE) is still associated with high morbidity and mortality rates. Use of synergistic antibiotic combinations is an appealing way to optimize therapy for IE. This review focuses on evidence-based recommendations for combination antimicrobial therapy for IE due...
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BACKGROUND extended spectrum β-lactamase (ESBL) producing gram negative bacilli are becoming a growing problem worldwide with difficulties in designing a national formulary for empirical treatment of gram negative sepsis. OBJECTIVES In this study, we investigated the in vitro activity of Carbapenems, Pipracillin-Tazobactam, Ciprofloxacin alone or in combination with aminoglycosides against ES...
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Combination antibiotic therapy for Gram-negative sepsis is controversial. The present review provides a brief summary of the existing knowledge on combination therapy for severe infections with multidrug-resistant Pseudomonas spp., Acinetobacter spp., and Enterobacteriaceae. Empirical combination antibiotic therapy is recommended for severe sepsis and septic shock to reduce mortality related to...
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ژورنال
عنوان ژورنال: mBio
سال: 2015
ISSN: 2161-2129,2150-7511
DOI: 10.1128/mbio.00120-15